Expression of Pin1, beta-catenin and cyclin D1 in salivary adenoid cystic carcinoma and its significance / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 623-626, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-293029
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of Pin1, beta-catenin and cyclin D1 in salivary adenoid cystic carcinomas (SACC) and to evaluate the role of beta-catenin and Pin1 in SACC carcinogenesis.</p><p><b>METHODS</b>The expressions of Pin1, beta-catenin and cyclin D1 were examined in the specimens of 65 patients with SACC by immunohistochemistry, and Pin1 protein and mRNA expressions detected by Western blot and RT-PCR in four SACC cell lines.</p><p><b>RESULTS</b>Pin1 was overexpressed in 51 cases of ACC (78%), and 41 (63%) cases showed positive immunoreactivity for cyclin D1 protein in the nuclear fraction in tumor tissues. Fourteen (22%) cases showed positive immunoreactivity for beta-catenin protein in the nuclear/cytoplasmic fraction in tumor tissues, 6 of which exhibited quite evident expression of beta-catenin in nucleolus. The expression of membranous beta-catenin was down-regulated in most of the patients with lymph node metastasis (11/14).</p><p><b>CONCLUSIONS</b>The results suggest that Pin1 and beta-catenin signalling pathway were activated in SACC and might play a pivotal role in SACC carcinogenesis and metastasis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Neoplasias das Glândulas Salivares
/
Carcinoma Adenoide Cístico
/
Peptidilprolil Isomerase
/
Ciclina D1
/
Linhagem Celular Tumoral
/
Beta Catenina
/
Peptidilprolil Isomerase de Interação com NIMA
/
Metástase Linfática
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Stomatology
Ano de publicação:
2006
Tipo de documento:
Artigo
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