Expression and significance of CD147 and E-cadherin in human gastric carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 515-519, 2009.
Article
em Zh
| WPRIM
| ID: wpr-293077
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of CD147 and E-cadherin in gastric carcinoma and their correlation with clinicopathological features.</p><p><b>METHODS</b>The expression of CD147 and E-cadherin in gastric cancer tissue chip (TC) was detected by in situ hybridization (ISH) and immunohistochemistry in 220 cases of gastric carcinoma and 31 cases with normal gastric mucosa.</p><p><b>RESULTS</b>The expression rates of CD147 mRNA, E-cadherin mRNA and E-cadherin protein were 50.5%, 17.7% and 15.5%, respectively. The CD147 expression was negatively correlated with E-cadherin expression. There was a significant relationship between CD147 mRNA expression and tumor diameter, TNM stage, invasion depth, vessel invasion, lymph node and distant metastasis. The E-cadherin mRNA expression was closely related with TNM stage, invasion depth and vascular invasion. There was a significant relationship between E-cadherin protein expression and tumor diameter, TNM stage and vascular invasion. The mean survival time in cases with CD147-positive expression was shorter than that in negative cases, while E-cadherin was in an opposite relationship.</p><p><b>CONCLUSION</b>In gastric carcinoma, up-regulation of CD147 and down-regulation of E-cadherin are in a negative correlation. The examination of both these two factors together is useful for predicting the invasion and metastasis of gastric cancer, therefore, can be used as a significant marker to direct clinic therapy and estimation of prognosis.</p>
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Índice:
WPRIM
Assunto principal:
Patologia
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Neoplasias Gástricas
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RNA Mensageiro
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Adenocarcinoma
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Adenocarcinoma Papilar
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Biomarcadores Tumorais
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Caderinas
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Regulação Neoplásica da Expressão Gênica
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Taxa de Sobrevida
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Carcinoma de Células em Anel de Sinete
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Ano de publicação:
2009
Tipo de documento:
Article