Study on rat nasal absorption in situ of borneol based on single pass perfusion method / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the absorption characteristic of borneol.</p><p><b>METHOD</b>Using single pass perfusion model, the active ingredient of borneol were detected by GC. The drug concentration, perfusion rate and pH value on the absorption of borneol were studied.</p><p><b>RESULT</b>Perfusion rate on the absorption rate constants (Ka) had significant effects. Drug concentration and pH value on the absorption rate constants had no significant impact.</p><p><b>CONCLUSION</b>the absorption of borneol is good by nasal. The absorption rate constants of borneol have no effected by drug concentration. The absorption of borneol is via a simple diffusion.</p>