Protective effect of purslane in a rat model of ulcerative colitis / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the protective effect of purslane on the acute injury caused by intra-colonic administration of trinitrobenzenesulfonic acid (TNBS) in rats.</p><p><b>METHOD</b>Seventy-two male SD rats were separated into 6 groups randomly. Rat model of ulcerative colitis was established by intra-colonic administration of trinitrobenzenesulfonic acid (TNBS). Purslane (2.5, 5, 10 g x kg(-1)) and sulfasalazine(0.5 g x kg(-1)) was administered by enemata, 3 days after TNBS instillation and daily during 10 days before killing the rats. Colons were removed for histological analysis and measurement of myeloperoxidase (MPO).</p><p><b>RESULT</b>Rats treated with purslane (5 and 10 g x kg(-1)) were significantly healthier than TNBS-alone rats, as shown by improved food intake and reduced diarrhea, corrected the disorders in morphology associated to lesions, significantly reduced myeloperoxidase (MPO) levels.</p><p><b>CONCLUSION</b>purslane exerts protective effect in experimental colitis, the effect seems to be related to relieving inflammatory reaction and repairing lesions.</p>