Screen for natural benzylisoquinoline alkaloids against tumor / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2684-2688, 2011.
Article
em Zh
| WPRIM
| ID: wpr-293239
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To search for natural benzylisoquinoline alkaloids against tumor.</p><p><b>METHOD</b>In this study, taken DNA as target, a method was developed for screening of natural benzylisoquinoline alkaloids against tumor from traditional Chinese medicine by the use of centrifugal ultrafiltration combined with HPLC technology. The anti-tumor activity for the compounds screened was evaluated in vitro.</p><p><b>RESULT</b>Nine compounds interacted with DNA were discovered and identified from Macleaya cordata, Chelidonium majus, Coptis chinensis, and the proliferation of four types of human solid cancer cell lines was markedly inhibited by these compounds.</p><p><b>CONCLUSION</b>The developed method was considered to be suitable for screening of natural benzylisoquinoline alkaloids against tumor from traditional Chinese medicine.</p>
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Índice:
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Assunto principal:
Farmacologia
/
Medicamentos de Ervas Chinesas
/
Química
/
Papaveraceae
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Chelidonium
/
Coptis
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Linhagem Celular Tumoral
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Benzilisoquinolinas
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Proliferação de Células
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Avaliação Pré-Clínica de Medicamentos
Limite:
Humans
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2011
Tipo de documento:
Article