Expression of FLI-1 and analysis of prognostic factors in primitive neuroectodermal tumor / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 917-920, 2010.
Article
em Zh
| WPRIM
| ID: wpr-293453
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the expression of FLI-1 in primitive neuroectodermal tumors (PNET), explore the value of immunohistochemical staining of FLI-1 in combination with other neural markers in diagnosis of PNET, and analyze the prognostic factors in PNET patients.</p><p><b>METHODS</b>35 cases of PNET, of which 33 cases with complete clinical data, were included in this study. Immmunohistochemistry (The En Vision method) was applied to detect the expression of FLI-1, CD99, Syn, NSE, S-100, NF, Vim in the tumor tissues. The clinicopathological data of 33 cases were analyzed by Cox regression.</p><p><b>RESULTS</b>The positive expression rate of FLI-1 were 51.4% and that of CD99 was 88.6%. The sensitivity of FLI-1 combined with CD99 was up to 100%. The positive rates of Vim, Syn, NSE, s-100 and NF were 91.4%, 48.6%, 45.7%, 22.9% and 0, respectively. Cox regression analysis showed that the impact of primary location and treatment modality were of statistical significance (P < 0.05), but the age, sex, stage or size of tumors did not (P > 0.05).</p><p><b>CONCLUSION</b>Immunohistochemical detection of FLI-1 and neural markers is a preferred method for clinical diagnosis of PNET. The main factors affecting the prognosis are the primary location of PNET and treatment modality.</p>
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Índice:
WPRIM
Assunto principal:
Patologia
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Neoplasias Pélvicas
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Fosfopiruvato Hidratase
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Terapêutica
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Vimentina
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Neoplasias Encefálicas
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Proteínas S100
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Antígenos CD
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Moléculas de Adesão Celular
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Modelos de Riscos Proporcionais
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Ano de publicação:
2010
Tipo de documento:
Article