Effect of the sustained release excipients on the release rate of ginsenoside Rg1 and ginsenoside Rb1 in sustained-release tablet of Panax notoginsenosides / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the influence of the sustained release excipient on the release rate of ginsenoside Rg1 and ginsenoside Rb1 in sustained-release tablet of Panax Notoginsenosides.</p><p><b>METHOD</b>The release rate of ginsenoside Rg1 and ginsenoside Rb1 in different matrix tablets with different excipient (HPMC, EC), different viscosity of EC (RT-50, RT-100), different ratio of EC in matrix tablet were detected.</p><p><b>RESULT</b>All above different factors influence the release rate of ginsenoside Rg1 and ginsenoside Rb1 and brought them different release curve.</p><p><b>CONCLUSION</b>Emphasis should be laid on the different release characteristic of different active compounds in active fraction.</p>