Anti-mutagenesis effects of total flavonoids of Astragalus / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1164-1167, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-293703
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the anti-mutagenic action of the total flavonoids of Astragalus (TFA).</p><p><b>METHOD</b>Three groups of concentrations of TFA and one inducer group were used. The anti-mutagenic action of TFA was studied by experiments in vitro and in vivo including miconucleolus assay, semen teraogenesis test and gene mutagenesis of V79/HGPRT.</p><p><b>RESULT</b>TFA did not affect the weight of the mice during the experiment period. The high concentration of TFA could significantly reduce cyclohophamide-induced miconucleolus number and gene mutagenesis of V79/HGPRT compared with inducer group. However, TFA did not make statistic change in the semen teraogenesis induced by mitomycin C.</p><p><b>CONCLUSION</b>TFA has antimutagenesis effect.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Plantas Medicinais
/
Testículo
/
Flavonoides
/
Testes para Micronúcleos
/
Células Cultivadas
/
Química
/
Mutagênese
/
Aberrações Cromossômicas
/
Cricetulus
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2003
Tipo de documento:
Artigo
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