Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction in patients undergoing coronary angiography / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1194-1197, 2003.
Artigo
em Inglês
| WPRIM
| ID: wpr-294134
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether coagulation factor VII (FVII) polymorphisms play a role in the pathogenesis of coronary artery disease (CAD) and/or myocardial infarction (MI) in a series of Hans.</p><p><b>METHODS</b>The Arg(353)Gln and HVR4 polymorphisms of FVII gene were determined in 374 patients undergoing selective coronary angiography by PCR and restriction fragment length polymorphism assay.</p><p><b>RESULTS</b>The FVII genotype distribution was in accordance with Hardy-Weinberg equilibrium. The frequencies of FVII genotypes or alleles did not show significant differences between the CAD group and the controls or between the males and the females. The frequencies of carriers of the Gln(353) allele and (Arg/Gln + Gln/Gln) genotypes were significantly higher in the CAD patients without MI than in those with MI (P = 0.031, odds ratio 0.37, 95% CI 0.15 - 0.94). However, HVR4 polymorphisms were not significantly different between the two groups (P > 0.05).</p><p><b>CONCLUSION</b>Carrying the F VII Gln(353) gene may be a protective factor against MI in the Chinese Hans.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Fator VII
/
China
/
Fatores de Risco
/
Angiografia Coronária
/
Povo Asiático
/
Genética
/
Infarto do Miocárdio
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2003
Tipo de documento:
Artigo
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