Gastrointestinal stromal tumor and its targeted therapeutics / 癌症
Chinese Journal of Cancer
; (12): 303-314, 2011.
Article
em En
| WPRIM
| ID: wpr-294518
Biblioteca responsável:
WPRO
ABSTRACT
Over the past 60 years, investigators of basic science, pathology, and clinical medicine have studied gastrointestinal stromal tumor (GIST) and made minor advances in patient care. Recent discoveries have led to an understanding of the biological role of KIT and platelet-derived growth factor receptor-α in GIST and the development of the tyrosine kinase inhibitor imatinib mesylate (Gleevec, formerly STI-571), one of the most exciting examples of targeted therapy to date. The success of targeted therapy in GIST has lead to new developments in our understanding of the medical and surgical management of the disease. Intense study of GIST may lead to new paradigms in the management of cancer.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
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Piperazinas
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Pirimidinas
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Cirurgia Geral
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Benzamidas
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Sistemas de Liberação de Medicamentos
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Terapia Combinada
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Proteínas Proto-Oncogênicas c-kit
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Receptor alfa de Fator de Crescimento Derivado de Plaquetas
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Usos Terapêuticos
Limite:
Humans
Idioma:
En
Revista:
Chinese Journal of Cancer
Ano de publicação:
2011
Tipo de documento:
Article