Gastrointestinal stromal tumor and its targeted therapeutics / 癌症
Chinese Journal of Cancer
;
(12): 303-314, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-294518
ABSTRACT
Over the past 60 years, investigators of basic science, pathology, and clinical medicine have studied gastrointestinal stromal tumor (GIST) and made minor advances in patient care. Recent discoveries have led to an understanding of the biological role of KIT and platelet-derived growth factor receptor-α in GIST and the development of the tyrosine kinase inhibitor imatinib mesylate (Gleevec, formerly STI-571), one of the most exciting examples of targeted therapy to date. The success of targeted therapy in GIST has lead to new developments in our understanding of the medical and surgical management of the disease. Intense study of GIST may lead to new paradigms in the management of cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Piperazinas
/
Pirimidinas
/
Cirurgia Geral
/
Benzamidas
/
Sistemas de Liberação de Medicamentos
/
Terapia Combinada
/
Proteínas Proto-Oncogênicas c-kit
/
Receptor alfa de Fator de Crescimento Derivado de Plaquetas
/
Usos Terapêuticos
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Cancer
Ano de publicação:
2011
Tipo de documento:
Artigo
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