Mechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids / 대한해부학회지
Anatomy & Cell Biology
; : 16-24, 2015.
Article
em En
| WPRIM
| ID: wpr-29475
Biblioteca responsável:
WPRO
ABSTRACT
Pancreatic islets are responsible for blood glucose homeostasis. Reduced numbers of functional (insulin-secreting) beta-cells in pancreatic islets underlies diabetes. Restoration of the secretion of the proper amount of insulin is a goal. Beta-cell mass is increased by neogenesis, proliferation and cell hypertrophy, and is decreased by beta-cell death primarily through apoptosis. Many hormones and nutrients affect beta-cell mass, and glucose and free fatty acid are thought to be the most important determinants of beta-cell equilibrium. A number of molecular pathways have been implicated in beta-cell mass regulation and have been studied. This review will focus on the role of the principle metabolites, glucose and free fatty acid, and the downstream signaling pathways regulating beta-cell mass by these metabolites.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Glicemia
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Ilhotas Pancreáticas
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Apoptose
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Ácidos Graxos não Esterificados
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Glucose
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Homeostase
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Hipertrofia
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Insulina
Idioma:
En
Revista:
Anatomy & Cell Biology
Ano de publicação:
2015
Tipo de documento:
Article