Haplotypes analysis of the prostacyclin synthase gene and myocardial infarction in Uigur population / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 115-119, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-294767
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between the polymorphisms and haplotypes of prostacyclin synthase gene with MI in Uigur patients in Xinjiang.</p><p><b>METHODS</b>210 patients with MI and 206 healthy control subjects were genotyped for 3 SNPs of the human prostacyclin synthase gene by polymerase chain reaction and restriction fragment length polymorphism.</p><p><b>RESULTS</b>The genotype distributions of the control group and MI group were in the Hardy-Weinberg equilibrium (both P > 0.05). The frequency of CC of rs5629 in MI group was significantly higher than that in controls (71.42% vs. 61.65%, P = 0.035). The frequency of A-C-T haplotype was significantly higher in the control group than that in the MI patients (4.01% vs. 0.60%, P = 0.001). The frequency of C-T-T haplotype was significantly higher in the MI patients than that in the controls (7.40% vs. 3.31%, P = 0.011). Logistic regression analysis showed that, after adjusting hypertension, hyperlipemia and smoking, the CC genotype of rs5629 (P = 0.021, OR = 1.665, 95%CI 1.024 - 2.156) and the C-T-T haplotype (P = 0.011, OR = 1.876, 95%CI 1.410 - 3.171) was the independent risk factors for MI.</p><p><b>CONCLUSION</b>The CC genotype of rs5629 and the C-T-T haplotype of prostacyclin synthase gene are associated with MI but the A-C-T haplotype of prostacyclin synthase gene might be a protective factor of MI in Uigur population of Xinjiang.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Haplótipos
/
Oxirredutases Intramoleculares
/
Polimorfismo de Nucleotídeo Único
/
Sistema Enzimático do Citocromo P-450
/
Povo Asiático
/
Etnologia
/
Frequência do Gene
/
Genética
/
Genótipo
/
Infarto do Miocárdio
Tipo de estudo:
Fatores de risco
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2009
Tipo de documento:
Artigo
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