Haplotypes analysis of the prostacyclin synthase gene and myocardial infarction in Uigur population / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 115-119, 2009.
Article
em Zh
| WPRIM
| ID: wpr-294767
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between the polymorphisms and haplotypes of prostacyclin synthase gene with MI in Uigur patients in Xinjiang.</p><p><b>METHODS</b>210 patients with MI and 206 healthy control subjects were genotyped for 3 SNPs of the human prostacyclin synthase gene by polymerase chain reaction and restriction fragment length polymorphism.</p><p><b>RESULTS</b>The genotype distributions of the control group and MI group were in the Hardy-Weinberg equilibrium (both P > 0.05). The frequency of CC of rs5629 in MI group was significantly higher than that in controls (71.42% vs. 61.65%, P = 0.035). The frequency of A-C-T haplotype was significantly higher in the control group than that in the MI patients (4.01% vs. 0.60%, P = 0.001). The frequency of C-T-T haplotype was significantly higher in the MI patients than that in the controls (7.40% vs. 3.31%, P = 0.011). Logistic regression analysis showed that, after adjusting hypertension, hyperlipemia and smoking, the CC genotype of rs5629 (P = 0.021, OR = 1.665, 95%CI: 1.024 - 2.156) and the C-T-T haplotype (P = 0.011, OR = 1.876, 95%CI: 1.410 - 3.171) was the independent risk factors for MI.</p><p><b>CONCLUSION</b>The CC genotype of rs5629 and the C-T-T haplotype of prostacyclin synthase gene are associated with MI but the A-C-T haplotype of prostacyclin synthase gene might be a protective factor of MI in Uigur population of Xinjiang.</p>
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Índice:
WPRIM
Assunto principal:
Haplótipos
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Oxirredutases Intramoleculares
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Polimorfismo de Nucleotídeo Único
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Sistema Enzimático do Citocromo P-450
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Povo Asiático
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Etnologia
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Frequência do Gene
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Genética
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Genótipo
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Infarto do Miocárdio
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2009
Tipo de documento:
Article