Synthesis and antithrombotic activity of acetylsalicyl ferulic acid-coupling furoxans and nitrates / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1050-1056, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-294890
ABSTRACT
<p><b>AIM</b>To synthesize and study the antithrombotic activity of NO-donating aspirin derivatives.</p><p><b>METHODS</b>Furoxans and nitrates were incorporated to aspirin via antioxidant ferulic acid as a linker, and the target compounds were screened for in vitro and in vivo inhibitory activities of platelet aggregation, and for inhibitory effect on A-V hypass thromhosis in rats.</p><p><b>RESULTS</b>Fourteen novel compounds I(1-14), were synthesized and their structures were confirmed Iy MS, IR, 1H NMR and elemental analysis. Biological screening results demonstrated that some tested compounds exhibited potential antithrombotic activ it.</p><p><b>CONCLUSION</b>Acetylsalicyl ferulic acid-coupling furoxans and nitrates might he used as a lead for further study.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxidiazóis
/
Farmacologia
/
Inibidores da Agregação Plaquetária
/
Estrutura Molecular
/
Química
/
Agregação Plaquetária
/
Aspirina
/
Doadores de Óxido Nítrico
/
Ácidos Cumáricos
/
Fibrinolíticos
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2006
Tipo de documento:
Artigo
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