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Combined effect of cosolvent and cyclodextrin on solubilization of insoluble drugs / 药学学报
Acta Pharmaceutica Sinica ; (12): 950-955, 2006.
Artigo em Chinês | WPRIM | ID: wpr-294907
ABSTRACT
<p><b>AIM</b>To investigate the combined effect of cosolvent and cyclodextrin (CD) on solubilization of insoluble drugs.</p><p><b>METHODS</b>Phase-solubility method was applied to determine solubilization of two diterpenoids in cosolvent / cyclodextrin combinations. The combined effect was evaluated and explained with an established mathematical model, and the model parameters were calculated by means of nonlinear regression analysis.</p><p><b>RESULTS</b>The strong agreement between the predicted and the observed solubility data supports the validity of the proposed model, with the determination coefficients of two regression models were 0.993 and 0.992, separately.</p><p><b>CONCLUSION</b>The validated mathematical model can be used to explain and predict the combined solubilization of the two insoluble drugs in different cosolvent systems.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Solubilidade / Solventes / Algoritmos / Água / Química / Beta-Ciclodextrinas / Diterpenos / 2-Hidroxipropil-beta-Ciclodextrina / Modelos Químicos Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Solubilidade / Solventes / Algoritmos / Água / Química / Beta-Ciclodextrinas / Diterpenos / 2-Hidroxipropil-beta-Ciclodextrina / Modelos Químicos Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2006 Tipo de documento: Artigo