Synthesis and bioactivity of 2-arylimino-4-thiazolidones / 药学学报
Acta Pharmaceutica Sinica
;
(12): 825-829, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-294931
ABSTRACT
<p><b>AIM</b>To synthesize a series of 2-arylimino-4-thiazolidone derivatives and 2-imidazolino [2,3-b]-4-thiazolidone in order to get some novel potent compounds with nitric oxide synthases (NOS) inhibitory activity.</p><p><b>METHODS</b>The target compounds were prepared by reaction of N-chloroacetyl-1,2,3,4-tetrahydroisoquinoline or N-chloroacetylphthalimide with substituted thioureas, their NOS inhibitory activity were measured.</p><p><b>RESULTS AND CONCLUSION</b>The 15 new compounds were synthesized and most of the reaction yields were over 65%. The structures of new compounds were identified by IR, 1H NMR, MS and elemental analyses. Bioassay indicated that, most of 15 new compounds synthesized had confirmed bioactivities inhibition against NOS.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Relação Estrutura-Atividade
/
Tiazóis
/
Tioureia
/
Estrutura Molecular
/
Química
/
Óxido Nítrico Sintase
/
Metabolismo
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2006
Tipo de documento:
Artigo
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