Antitumor effects of nobiletin on Heps and its mechanism / 药学学报
Acta Pharmaceutica Sinica
;
(12): 797-800, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-294936
ABSTRACT
<p><b>AIM</b>To study the inhibitory effect and mechanism of nobiletin on Heps tumor bearing mice.</p><p><b>METHODS</b>Models of Heps tumor bearing mice were established. The inhibitory rates of tumor growth were calculated, the apoptosis morphology of tumor tissue was observed. The T lymphocyte transformation capacity was tested by MTT assay, the TNFalpha and IL-2 production were measured by LDH kits.</p><p><b>RESULTS</b>Nobiletin could significantly inhibit Heps tumor growth. The inhibitory rates were 42.14% - 65.09% (P < 0.01). The morphology of tumor tissues in nobiletin group had typical characters of necrosis and apoptosis through transmission electron microscope. Nobiletin could stimulate T lymphocyte transformation and the production of TNFalpha and IL-2.</p><p><b>CONCLUSION</b>Nobiletin has obvious antitumor effect on Heps, the main mechanism is to enhance the cellular immune function and induce apoptosis of tumor tissue.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Plantas Medicinais
/
Linfócitos T
/
Transformação Celular Neoplásica
/
Química
/
Interleucina-2
/
Fator de Necrose Tumoral alfa
/
Citrus
/
Apoptose
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2006
Tipo de documento:
Artigo
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