Standard doses of tadalafil for different ED patients / 中华男科学杂志
National Journal of Andrology
;
(12): 860-863, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-294985
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of different doses of tadalafil on ED, and to search for appropriate doses for the treatment of different ED patients.</p><p><b>METHODS</b>Based on the baseline peak systolic velocity (PSV) of cavernosal arteries, 136 ED patients were divided into Groups A (PSV > 15 cm/s), B (PSV > 15 cm/s), C (PSV < 15 cm/s) and D (PSV <15 cm/s) to receive oral tadalafil at 10 mg (Groups A and C) and 5 mg (Groups B and D) on alternate days for 4 weeks. All of them were scored on IIEF-5 and detected for PSVs of the bilateral cavernosal arteries by color Doppler ultrasonography and intracavernous injection of prostaglandin E1 before and after the medication.</p><p><b>RESULTS</b>After 4 weeks of tadalafil treatment, IIEF-5 scores and PSVs were remarkably improved in all the four groups as compared with the baseline (P < 0.01), significantly higher in Group C than in D (P < 0.01), but with no significant differences between A and B.</p><p><b>CONCLUSION</b>Oral tadalafil can improve PSV and hence penile erection in ED patients either at a low or a high dose. To reduce side effects and drug cost, the patients with PSV >15 cm/s can be medicated at 5 mg, while those with PSV < 15 cm/s at 10 mg or more on alternate days.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Vasodilatadores
/
Ereção Peniana
/
Carbolinas
/
Resultado do Tratamento
/
Usos Terapêuticos
/
Relação Dose-Resposta a Droga
/
Tratamento Farmacológico
/
Tadalafila
/
Disfunção Erétil
Limite:
Adulto
/
Idoso
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2010
Tipo de documento:
Artigo
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