Apigenin affects semen parameters in male mice / 中华男科学杂志
National Journal of Andrology
;
(12): 778-782, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-295002
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of apigenin on semen parameters in male mice.</p><p><b>METHODS</b>Totally 100 healthy male mice of Kunming strain were randomly divided into 5 groups according to the body weight negative control, solvent control, low-dose apigenin, median-dose apigenin and high-dose apigenin, the latter three groups given intragastric apigenin at a fixed time every day for 7 and 14 days. At 35 days after the first medication, all the mice were killed and detected for the sperm motion parameters by computer aided sperm analysis (CASA).</p><p><b>RESULTS</b>There were no statistically significant differences in sperm motion parameters, density and motility between the negative control and the three apigenin groups after 7-day medication. At 14 days, the high-dose apigenin group showed remarkable decreases in average path velocity (VAP), straight line velocity (VSL), straightness (STR), wobbliness (WOB), the percentage of grade b sperm and sperm motility, and a significant increase in beat cross frequency (BCF) as compared with the negative control group (P < 0.05).</p><p><b>CONCLUSION</b>Apigenin affects sperm motility in male mice to a certain extent.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Sêmen
/
Motilidade dos Espermatozoides
/
Apigenina
/
Camundongos Endogâmicos
Limite:
Animais
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2010
Tipo de documento:
Artigo
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