Preparation and quality evaluation of intravenous tanshinone II (A) emulsion / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1249-1252, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-295374
ABSTRACT
<p><b>OBJECTIVE</b>To prepare and evaluate an intravenous emulsion of tanshinone II(A).</p><p><b>METHOD</b>Soybean phospholipid mixing with poloxamer 188 was used as emulsifier. Oleic acid and glycerol were used as co-emulsifier and isoosmotic adjusting agent, respectively. The coarse emulsion was first prepared and following homogenization was carried out for the coarse emulsion by using a high pressure homogenizer.</p><p><b>RESULT</b>The average diameter of the prepared tanshinone II (A) emulsion was 211 nm with a zeta potential of -32. 1 mV. There had no changes of diameter, zeta potential, pH value, content and physical appearance for the tanshinone II (A) emulsion stored at 25 degrees C away from light during one year.</p><p><b>CONCLUSION</b>The physicochemical properties of the prepared tanshinone II (A) emulsion was stable, which could meet the requirements of intravenous administration.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho da Partícula
/
Fenantrenos
/
Controle de Qualidade
/
Temperatura
/
Centrifugação
/
Química
/
Abietanos
/
Estabilidade de Medicamentos
/
Armazenamento de Medicamentos
/
Emulsões
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Artigo
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