Influence of Zea mays L. saponin (ZMLS) on ultrastructure of kidney and pancreas in diabetes rats induced by streptozocin / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To discuss the effect of Zea mays L. saponin (ZMLS) on ultrastructure of kidney and pancreas in the diabetes rats induced by streptozocin.</p><p><b>METHOD</b>The diabetic rat model was established by injections of STZ, blood glucose, the ultrastructure of the kidney and pancreas were observed.</p><p><b>RESULT</b>Compared with the model group, the large, middle-dose ZMLS groups and melbinum group could remarkably decrease the blood glucose (P < 0.01), the large, middle, small-dose ZMLS groups could remarkably prevent the pancreatic islet beta-cell from the injury induced by Streptozotocin. Melbinum and the large, middle-dose ZMLS groups could remarkably increase mitochondrial Vv, deltam and euchromatin Vv (P < 0.01), and significantly decrease the delta, Nucleus delta and heterochromatin Vv (P < 0.01). The small dose of ZMLS obviously increases mitochondrial Vv (P < 0.05).</p><p><b>CONCLUSION</b>ZMLS showed good effect on decreasing blood glucose and protection action on the kidney and pancreas injury of induced by STZ.</p>