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Effect of several penetration enharcers on transdermal permeation and skin accumulation of artemether / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1130-1132, 2008.
Artigo em Chinês | WPRIM | ID: wpr-295397
ABSTRACT
<p><b>OBJECTIVE</b>To investigate penetration characteristics of artemether and the effect of different permeation enhancer on transdermal permeation of artemether through rat skin.</p><p><b>METHOD</b>The permeation experiments were performed using rat skin on modified Franz diffusion cells in vitro. The concentrations of artemether in receptor compartment at specified time points were determined by HPLC.</p><p><b>RESULT</b>The permeating ratio through human skin of artemether solution was Js (2.78 +/- 0.78) microg x cm(-2) x h(-1), the quantity of drug penetrated through and accumulated in the skin by the end of the experiment were (69.07 +/- 3.01) microg x cm(-2), (58.93 +/- 3.56) microg x cm(-2) respectively. Four different permeation enhancers can improve the transdermal permeation of artemether.</p><p><b>CONCLUSION</b>Artemether have the potential to be developed to new transdermal preparation.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Permeabilidade / Pele / Técnicas In Vitro / Medicamentos de Ervas Chinesas / Farmacocinética / Química / Adjuvantes Farmacêuticos / Ratos Wistar / Artemisininas / Metabolismo Limite: Animais Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Permeabilidade / Pele / Técnicas In Vitro / Medicamentos de Ervas Chinesas / Farmacocinética / Química / Adjuvantes Farmacêuticos / Ratos Wistar / Artemisininas / Metabolismo Limite: Animais Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2008 Tipo de documento: Artigo