Genotypic and clinical features of spinal muscular atrophy type 3 / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 218-221, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-295503
ABSTRACT
<p><b>OBJECTIVE</b>To explore the genotypic and clinical features and laboratory examinations of spinal muscular atrophy type 3 (SMA III).</p><p><b>METHODS</b>Results of genetic testing and laboratory exams of 18 SMA III patients were collected and analyzed.</p><p><b>RESULTS</b>The average age of onset of patients was 6.1 years, with the course of disease lasting from 13 months to 28 years. All patients became symptomatic with lower extremity muscle weakness. The symptoms gradually aggregated, with proximal lower limb muscle becoming atrophic and proximal upper limb muscle becoming weak. Genetic testing indicated that all subjects possessed homozygous deletions of SMN1 gene. Electromyography (EMG) of 15 subjects indicated neurogenic damage. Whilst younger patients had normal level of creatine kinase (CK), elder patients had higher level of CK, though no linear correlation was found.</p><p><b>CONCLUSION</b>Full understanding of Clinical, especially the growth features of SMA III, in combination with genetic testing, can facilitate diagnosis and early intervention of the disease.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Atrofias Musculares Espinais da Infância
/
Testes Genéticos
/
Idade de Início
/
Diagnóstico
/
Proteína 1 de Sobrevivência do Neurônio Motor
/
Genética
/
Genótipo
/
Métodos
Tipo de estudo:
Estudo diagnóstico
Limite:
Adolescente
/
Adulto
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2012
Tipo de documento:
Artigo
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