A versatile role of transcription regulator CTCF in epigenetics and diseases / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 176-180, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-295512
ABSTRACT
CTCF as a multivalent eukaryotic transcription factor plays a diverse range of roles in regulation of various genes through the binding of its 11 zinc fingers to CTCF consensus sites or various proteins. CTCF is involved in multiple aspects of epigenetic regulation including regulation of chromatin remodeling and genomic imprinting. Deregulation of these processes result in a group of diseases are characterized by growth, development, and neurological dysfunction. This paper reviews recent researches that highlight the links between CTCF, epigenetics and diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteínas Repressoras
/
Fatores de Transcrição
/
Doença
/
Dedos de Zinco
/
Epigenômica
/
Fator de Ligação a CCCTC
/
Genética
/
Métodos
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2012
Tipo de documento:
Artigo
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