A new human leukocyte antigen class I allele, HLA- B*52:11 / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 712-715, 2011.
Article
em Zh
| WPRIM
| ID: wpr-295547
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To identify and confirm a novel HLA allele.</p><p><b>METHODS</b>A new human leukocyte antigen class I allele was found during routine HLA genotyping by polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) and sequencing-based typing (SBT).</p><p><b>RESULTS</b>The novel HLA-B*52 allele was identical to B*52:01:01 with an exception of one base substitution at position 583 of exon 3 where a C was changed to T resulting in codon 195 changed from CAC(H) to TAC(Y).</p><p><b>CONCLUSION</b>A new HLA class I allele, B*52:11, is identified, and is named officially by the WHO Nomenclature Committee.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Dados de Sequência Molecular
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Sequência de Bases
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Antígenos HLA-B
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Alinhamento de Sequência
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Sequência de Aminoácidos
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Análise de Sequência de DNA
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Alelos
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Genética
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Genótipo
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2011
Tipo de documento:
Article