Association of ABCG2 gene C421A polymorphism and susceptibility of primary gout in Han Chinese males / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 683-685, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-295554
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association between a C421A single nucleotide polymorphism (SNP) in exon 5 of ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2) gene and susceptibility of primary gout in Han Chinese males.</p><p><b>METHODS</b>For 200 male patients with primary gout and 235 controls, the genotype of C421A locus was analyzed by PCR and direct sequencing. Blood glucose, uric acid, total cholesterol, triglycerides, creatinine and urea nitrogen was measured by an automatic biochemical analyzer.</p><p><b>RESULTS</b>Compared with the controls, there was a higher frequency for AA genotype and A allele of the rs2231142 SNP in gout patients (22.5% vs. 8.5% by genotype; 44.9% vs. 32.3% by allele). The association with gout reached significance (chi-square =15.91, P< 0.001, crude OR=3.02, 95% CI1.36-4.90 and OR (adjusted by age)=1.80, 95% CI 1.32-2.45 by dominant mode; chi-square=6.82, P=0.009, OR=1.67, 95% CI 1.54-2.27 by recessive mode). Blood glucose, uric acid, triglycerides, creatinine and urea nitrogen levels in gout patients were significantly higher than those of controls (P< 0.001).</p><p><b>CONCLUSION</b>The C421A SNP, in particular AA phenotype, may be associated with susceptibility of primary gout in Han Chinese males.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estudos de Casos e Controles
/
China
/
Transportadores de Cassetes de Ligação de ATP
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
/
Alelos
/
Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP
/
Frequência do Gene
/
Genética
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2011
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS