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Curative effect of pemetrexed on the treatment of relapsed primary central nervous system lymphoma / 中华血液学杂志
Chinese Journal of Hematology ; (12): 46-49, 2014.
Article em Zh | WPRIM | ID: wpr-295721
Biblioteca responsável: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the efficacy and safety of pemetrexed in the treatment of relapsed primary central nervous system lymphoma (PCNSL).</p><p><b>METHODS</b>Seven cases with relapsed PCNSL admitted in our hospital between August 2012 and August 2013 were retrospectively reviewed.</p><p><b>RESULTS</b>Of the 7 relapsed cases, ectopic recurrence occurred in 3, in situ recurrence in 3 and leptomeningeal metastasis in 1. Patients with relapsed PCNSL were administered with high-dose pemetrexed (900 mg/m²) once for every 3 weeks and supplemented with folic acid and vitamin B₁₂. Complete remission was obtained in 2 patients, partial remission in 3 patients and progressive disease in 2. The overall response rate was 71.4% (5/7). The main adverse reactions were myelosuppression and gastrointestinal reaction.</p><p><b>CONCLUSION</b>Treatment of relapsed PCNSL is difficult, and its prognosis is very poor. Pemetrexed therapy is a meaningful trial.</p>
Assuntos
Texto completo: 1 Índice: WPRIM Assunto principal: Patologia / Prognóstico / Estudos Retrospectivos / Linfoma Difuso de Grandes Células B / Neoplasias do Sistema Nervoso Central / Usos Terapêuticos / Tratamento Farmacológico / Pemetrexede / Glutamatos / Guanina Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male Idioma: Zh Revista: Chinese Journal of Hematology Ano de publicação: 2014 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Patologia / Prognóstico / Estudos Retrospectivos / Linfoma Difuso de Grandes Células B / Neoplasias do Sistema Nervoso Central / Usos Terapêuticos / Tratamento Farmacológico / Pemetrexede / Glutamatos / Guanina Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male Idioma: Zh Revista: Chinese Journal of Hematology Ano de publicação: 2014 Tipo de documento: Article