The relationship between nonresponse to hepatitis B vaccine and HLA genotype/haplotype / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 180-183, 2002.
Artigo
em Inglês
| WPRIM
| ID: wpr-295776
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between the nonresponse to hepatitis B vaccine and HLA genotype/heplotype in Chinese population and provide the evidence for explaining the genetic mechanism of this nonresponse.</p><p><b>METHODS</b>Our research focused on the relationship between nonresponse to Hepatitis B vaccine and HLA-DRB1, DRB3, DRB4, DRB5 and DQB1 genotype/haplotype in Chinese population, collected from a community in Guangxi Zhuang Autonomous Region. The group specific amplification was employed to characterize 107 individuals' genotype and haplotype of HLA clusters. Different models statistics such as relative risk test, correlation test and linkage disequilibrium analysis were used to analyze the data.</p><p><b>RESULTS</b>The results showed that there is a linkage disequilibrium between nonresponse to Hepatitis B vaccine and HLA haplotype DR4, 1122 (DRB1 * 0401- 22, 1122)-DR53 (DRB4 * 0101101, 0102/3)-DQB4 (DQB1 * 04).</p><p><b>CONCLUSION</b>In Chinese population, nonresponse to hepatitis B vaccine is highly associated with special HLA haplotye.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Haplótipos
/
Antígenos HLA-DQ
/
Antígenos HLA-DR
/
Desequilíbrio de Ligação
/
China
/
Classificação
/
Vacinas contra Hepatite B
/
Povo Asiático
/
Alergia e Imunologia
/
Cadeias beta de HLA-DQ
Tipo de estudo:
Estudo de etiologia
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Chinese Journal of Preventive Medicine
Ano de publicação:
2002
Tipo de documento:
Artigo
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