The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China / 癌症
Chinese Journal of Cancer
;
(12): 410-414, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-295819
ABSTRACT
V-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4) has been reported to be somatically mutated in 19% of melanoma cases. To investigate the prevalence of ERBB4 mutations in melanoma patients from southern China, we analyzed 117 formalin-fixed, paraffin-embedded melanoma samples archived in the Sun Yat-sen University Cancer Center. A matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) platform was used to screen for mutations. No ERBB4 hotspot mutations were detected. Our results indicate that ERBB4 mutations may play a limited role in melanomas in China; therefore, targeting the ERBB4 mutation in melanoma patients from southern China may not be a promising strategy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Cutâneas
/
DNA de Neoplasias
/
Inclusão em Parafina
/
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
/
Povo Asiático
/
Extremidades
/
Receptores ErbB
/
Receptor ErbB-4
/
Genética
/
Melanoma
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Chinese Journal of Cancer
Ano de publicação:
2013
Tipo de documento:
Artigo
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