The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China / 癌症
Chinese Journal of Cancer
; (12): 410-414, 2013.
Article
em En
| WPRIM
| ID: wpr-295819
Biblioteca responsável:
WPRO
ABSTRACT
V-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4) has been reported to be somatically mutated in 19% of melanoma cases. To investigate the prevalence of ERBB4 mutations in melanoma patients from southern China, we analyzed 117 formalin-fixed, paraffin-embedded melanoma samples archived in the Sun Yat-sen University Cancer Center. A matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) platform was used to screen for mutations. No ERBB4 hotspot mutations were detected. Our results indicate that ERBB4 mutations may play a limited role in melanomas in China; therefore, targeting the ERBB4 mutation in melanoma patients from southern China may not be a promising strategy.
Texto completo:
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Índice:
WPRIM
Assunto principal:
Neoplasias Cutâneas
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DNA de Neoplasias
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Inclusão em Parafina
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Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
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Povo Asiático
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Extremidades
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Receptores ErbB
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Receptor ErbB-4
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Genética
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Melanoma
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Chinese Journal of Cancer
Ano de publicação:
2013
Tipo de documento:
Article