Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence (PEST) / 癌症
Chinese Journal of Cancer
;
(12): 75-83, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-295829
ABSTRACT
Protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-, and threonine-rich sequence (PEST) is ubiquitously expressed and is a critical regulator of cell adhesion and migration. PTP-PEST activity can be regulated transcriptionally via gene deletion or mutation in several types of human cancers or via post-translational modifications, including phosphorylation, oxidation, and caspase-dependent cleavage. PTP-PEST interacts with and dephosphorylates cytoskeletal and focal adhesion-associated proteins. Dephosphorylation of PTP-PEST substrates regulates their enzymatic activities and/or their interaction with other proteins and plays an essential role in the tumor cell migration process.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxirredução
/
Patologia
/
Fosforilação
/
Adesão Celular
/
Movimento Celular
/
Processamento de Proteína Pós-Traducional
/
Quinases da Família src
/
Proteínas rho de Ligação ao GTP
/
Proteína-Tirosina Quinases de Adesão Focal
/
Proteína Tirosina Fosfatase não Receptora Tipo 12
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Cancer
Ano de publicação:
2013
Tipo de documento:
Artigo
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