Application of next-generation sequencing in clinical oncology to advance personalized treatment of cancer / 癌症
Chinese Journal of Cancer
;
(12): 463-470, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-295842
ABSTRACT
With the development and improvement of new sequencing technology, next-generation sequencing (NGS) has been applied increasingly in cancer genomics research over the past decade. More recently, NGS has been adopted in clinical oncology to advance personalized treatment of cancer. NGS is used to identify novel and rare cancer mutations, detect familial cancer mutation carriers, and provide molecular rationale for appropriate targeted therapy. Compared to traditional sequencing, NGS holds many advantages, such as the ability to fully sequence all types of mutations for a large number of genes (hundreds to thousands) in a single test at a relatively low cost. However, significant challenges, particularly with respect to the requirement for simpler assays, more flexible throughput, shorter turnaround time, and most importantly, easier data analysis and interpretation, will have to be overcome to translate NGS to the bedside of cancer patients. Overall, continuous dedication to apply NGS in clinical oncology practice will enable us to be one step closer to personalized medicine.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Análise de Sequência de DNA
/
Economia
/
Medicina de Precisão
/
Sequenciamento de Nucleotídeos em Larga Escala
/
Genética
/
Métodos
/
Mutação
/
Neoplasias
Tipo de estudo:
Avaliação Econômica em Saúde
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Cancer
Ano de publicação:
2012
Tipo de documento:
Artigo
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