The Effect of Mitomycin-C on Postoperative Corneal Astigmatism in Trabeculectomy and Triple Procedure

ABSTRACT

Mitomycin-C is known to delay wound healing and it may have influence upon the post operative astigmatism changes. We calculated the postoperative induced astigmatism of patients who underwent trabeculectomy or triple procedures with or without the use of mitomycin-C. And the vector analysis method was used. To compare the induced astigmatism between the groups we calculated the induced astigmatism corresponding to the 180degree axis. The patients who underwent triple procedure without and with mitomycin-C showed a mean induced astigmatism of -4.50D, -1.81D, respectively, after 7 days(p<0.05) and -0.13D, 1.73D, respectively, after 12 months (p<0.05). Those who underwent trabeculectomy without mitomycin-C and with mitomycin-C showed a mean induced astigmatism of -2.63D, -1.01D, respectively, after 1 month(p<0.05) and -1.42D, 0.34D, respectively, after 12 months(p<0.05). The use of mitomycin-C reduces the total amount of astigmatism in trabeculectomy patients. However, in the triple procedure patients it increases the total amount of astigmatism. The entire amount of against the rule astigmatic change was similar between the mitomycin-C applied group and non-applied group. The astigmatic shift of the group without mitomycin-C, reached a plateau after 3 months. However, the other group showed continuous against the rule shift until 12 months.