Impacts of ABO incompatibility on early outcome after single unit unrelated cord blood transplantation: a retrospective single center experience / 中华血液学杂志
Chinese Journal of Hematology
; (12): 999-1004, 2015.
Article
em Zh
| WPRIM
| ID: wpr-296100
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To retrospectively study the impacts of ABO incompatibility on early outcome after single unit unrelated cord blood transplantation(UCBT), such as cumulative incidence of engraftment, incidence of acute graft- versus- host disease (aGVHD) and 180- day transplant- related mortality(TRM).</p><p><b>METHODS</b>208 patients underwent single unit UCBT from April 2008 to October 2014 were analyzed, included 99 ABO- identical, 60 minor, 38 major and 11 bidirectional ABO- incompatible recipients. All the patients received intensified myeloablative conditioning, and a combination of cyclosporine A and mycophenolate mofetil was given for GVHD prophylaxis.</p><p><b>RESULTS</b>Cumulative incidences of neutrophil engraftment, platelet recovery, erythroid lineage reconstitution, Ⅱ-Ⅳ aGVHD, Ⅲ-Ⅳ aGVHD and 180- day TRM showed no significant difference among the patients receiving ABOidentical, minor, major, and bidirectional UCBT(all P>0.05, respectively). What's more, none of the patients developed pure red- cell aplasia(PRCA)after UCBT. Group A donor and a group O recipient patients didn't appeared to influence the clinical results when compared with others(all P>0.05, respectively).</p><p><b>CONCLUSION</b>Patients receive ABO- incompatible UCBT may not develop PRCA. The presence of ABO- incompatibility did not influence the hematopoietic reconstitution, the incidence of aGVHD and 180-day TRM in this cohort. There is not support for the need to regard ABO-compatibility as an UCB-graft selection criterion.</p>
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Índice:
WPRIM
Assunto principal:
Doadores de Tecidos
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Transplante Homólogo
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Incompatibilidade de Grupos Sanguíneos
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Sistema ABO de Grupos Sanguíneos
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Estudos Retrospectivos
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Ciclosporina
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Aplasia Pura de Série Vermelha
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Transplante de Células-Tronco de Sangue do Cordão Umbilical
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Usos Terapêuticos
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Doença Enxerto-Hospedeiro
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Hematology
Ano de publicação:
2015
Tipo de documento:
Article