HTLV-1 bZIP Factor (HBZ): Roles in HTLV-1 Oncogenesis / 病毒学报
Chinese Journal of Virology
;
(6): 235-242, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-296191
ABSTRACT
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus demonstrated to be associated with human disease. Infection by the HTLV-1 can cause T-cell leukemia (ATL) in adults. HTLV-1 bZIP factor (HBZ) is a viral protein encoded by the minus strand of the HTLV-1 provirus. Among the regulatory and accessory genes of HTLV-1, HBZ is the only gene that remains intact and which is expressed consistently in all patients with ATL. Moreover, HBZ has a critical role in the leukemogenesis of ATL. Here, we review the function of HBZ in the oncogenesis of HTLV-1 and its molecular mechanism of action.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Virologia
/
Vírus Linfotrópico T Tipo 1 Humano
/
Infecções por HTLV-I
/
Leucemia de Células T
/
Proteínas dos Retroviridae
/
Fatores de Transcrição de Zíper de Leucina Básica
/
Carcinogênese
/
Genética
/
Metabolismo
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Virology
Ano de publicação:
2016
Tipo de documento:
Artigo
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