Research Progress in Mechanisms Associated with Latent Infection in Humans by the Cytomegalovirus / 病毒学报
Chinese Journal of Virology
;
(6): 82-87, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-296213
ABSTRACT
The human cytomegalovirus (HCMV) is a widespread herpesvirus. Virus reactivation from latency can lead to stillbirth, miscarriage, fetal anomalies, and intrauterine growth retardation. During latent infection with the HCMV, the virus can be cleared by the immune response or apoptosis of host cells. However, the HCMV has developed several strategies to manipulate expression of its genes and the microenvironment of host cells. Recent studies have shown that latent infection with the HCMV is associated with viral regulation of early expression of genes; evasion of cell death; evasion of the immune response; regulatin of non-coding RNAs. This review summarizes recent research progress on the mechanisms underpinning latent infection with the HCMV.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Proteínas Virais
/
Virologia
/
Latência Viral
/
Infecções por Citomegalovirus
/
Citomegalovirus
/
Alergia e Imunologia
/
Genética
/
Metabolismo
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Virology
Ano de publicação:
2016
Tipo de documento:
Artigo
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