Advancement and prospects of tumor gene therapy / 癌症
Chinese Journal of Cancer
;
(12): 182-188, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-296298
ABSTRACT
Gene therapy is one of the most attractive fields in tumor therapy. In past decades, significant progress has been achieved. Various approaches, such as viral and non-viral vectors and physical methods, have been developed to make gene delivery safer and more efficient. Several therapeutic strategies have evolved, including gene-based (tumor suppressor genes, suicide genes, antiangiogenic genes, cytokine and oxidative stress-based genes) and RNA-based (antisense oligonucleotides and RNA interference) approaches. In addition, immune response-based strategies (dendritic cell- and T cell-based therapy) are also under investigation in tumor gene therapy. This review highlights the progress and recent developments in gene delivery systems, therapeutic strategies, and possible clinical directions for gene therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapêutica
/
Células Dendríticas
/
Terapia Genética
/
Genes Supressores de Tumor
/
Técnicas de Transferência de Genes
/
Interferência de RNA
/
Genes Transgênicos Suicidas
/
Alergia e Imunologia
/
Vetores Genéticos
/
Genética
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Cancer
Ano de publicação:
2011
Tipo de documento:
Artigo
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