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Animal models of melanoma: a somatic cell gene delivery mouse model allows rapid evaluation of genes implicated in human melanoma / 癌症
Chinese Journal of Cancer ; (12): 153-162, 2011.
Artigo em Inglês | WPRIM | ID: wpr-296301
ABSTRACT
The increasing incidence and mortality associated with advanced stages of melanoma are cause for concern. Few treatment options are available for advanced melanoma and the 5-year survival rate is less than 15%. Targeted therapies may revolutionize melanoma treatment by providing less toxic and more effective strategies. However, maximizing effectiveness requires further understanding of the molecular alterations that drive tumor formation, progression, and maintenance, as well as elucidating the mechanisms of resistance. Several different genetic alterations identified in human melanoma have been recapitulated in mice. This review outlines recent progress made in the development of mouse models of melanoma and summarizes what these findings reveal about the human disease. We begin with a discussion of traditional models and conclude with the recently developed RCAS/TVA somatic cell gene delivery mouse model of melanoma.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Receptores Virais / Neoplasias Cutâneas / Melanoma Experimental / Acetato de Tetradecanoilforbol / Camundongos Transgênicos / Técnicas de Transferência de Genes / Vírus da Leucose Aviária / Transgenes / Proteínas Aviárias Tipo de estudo: Estudo prognóstico Limite: Animais / Humanos Idioma: Inglês Revista: Chinese Journal of Cancer Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Receptores Virais / Neoplasias Cutâneas / Melanoma Experimental / Acetato de Tetradecanoilforbol / Camundongos Transgênicos / Técnicas de Transferência de Genes / Vírus da Leucose Aviária / Transgenes / Proteínas Aviárias Tipo de estudo: Estudo prognóstico Limite: Animais / Humanos Idioma: Inglês Revista: Chinese Journal of Cancer Ano de publicação: 2011 Tipo de documento: Artigo