Effects of vitamin A, C and E, or omega-3 fatty acid supplementation on the level of paraoxonase and arylesterase activity in streptozotocin-induced diabetic rats: an investigation of activities in plasma, and heart and liver homogenates
Singapore medical journal
;
: 153-156, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-296459
ABSTRACT
<p><b>INTRODUCTION</b>This study was designed and conducted to evaluate the effects of vitamin A, C and E supplementation, and omega-3 fatty acid supplementation on the activity of paraoxonase and arylesterase in an experimental model of diabetes mellitus.</p><p><b>METHODS</b>A total of 64 male Sprague Dawley® rats, each weighing 250 g, were randomly distributed into four groups (a) normal control; (b) diabetic control; (c) diabetic with vitamin A, C and E supplementation; and (d) diabetic with omega-3 fatty acid supplementation. The animals were anaesthetised after four weeks of intervention, and paraoxonase and arylesterase activity in blood plasma, and liver and heart homogenates were measured.</p><p><b>RESULTS</b>Arylesterase activity in the heart and liver homogenates was significantly lower in the diabetic control group than in the normal control group (p < 0.01). Vitamin A, C and E supplementation, and omega-3 fatty acid supplementation significantly increased liver arylesterase activity (p < 0.05). No significant change was observed in paraoxonase activity and other investigated factors.</p><p><b>CONCLUSION</b>Vitamin A, C and E, or omega-3 fatty acid supplementation were found to increase liver arylesterase activity in streptozotocin-induced diabetic rats. These supplements may be potential agents for the treatment of diabetes mellitus complications.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Ácido Ascórbico
/
Vitamina A
/
Vitaminas
/
Hidrolases de Éster Carboxílico
/
Ácidos Graxos Ômega-3
/
Ratos Sprague-Dawley
/
Suplementos Nutricionais
/
Arildialquilfosfatase
/
Diabetes Mellitus Experimental
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Singapore medical journal
Ano de publicação:
2016
Tipo de documento:
Artigo
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