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Prevalence and Risk Factors Associated with Adverse Drug Reactions among Previously Treated Tuberculosis Patients in China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 139-142, 2017.
Artigo em Inglês | WPRIM | ID: wpr-296505
ABSTRACT
We assessed the incidence of adverse drug reactions (ADRs) with anti-TB medications and evaluated the risk factors for developing ADRs in previously treated tuberculosis patients in China. All patients received the first-line anti-TB regimen (2HREZS/6HRE) as recommended by the national guidelines. Clinical and laboratory evaluations were performed once a month. Out of the 354 participants, 262 (74.0%) experienced ADRs such as hyperuricemia (65.0%, 230/354), hepatotoxicity (6.2%, 22/354) and hearing disturbances (4.8%, 17/354). ADRs were significantly associated with diabetes mellitus [OR (95% CI) 15.5 (2.07-115.87)]; however, weight more than 50 kg [OR (95% CI) 0.41 (0.22-0.85)] was a protective factor for occurrence of ADRs. Hyperuricemia is the most common adverse event but, most patients with hyperuricemia showed increased tolerance for high uric acid levels. Low body weight and diabetes mellitus increased the risk of the occurrence of ADRs during anti-TB treatment.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tuberculose Pulmonar / Epidemiologia / Prevalência / Estudos Retrospectivos / Fatores de Risco / Usos Terapêuticos / Diabetes Mellitus / Tratamento Farmacológico / Antituberculosos Tipo de estudo: Estudo de etiologia / Guia de Prática Clínica / Estudo observacional / Estudo de prevalência / Fatores de risco Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Biomedical and Environmental Sciences Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Tuberculose Pulmonar / Epidemiologia / Prevalência / Estudos Retrospectivos / Fatores de Risco / Usos Terapêuticos / Diabetes Mellitus / Tratamento Farmacológico / Antituberculosos Tipo de estudo: Estudo de etiologia / Guia de Prática Clínica / Estudo observacional / Estudo de prevalência / Fatores de risco Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Biomedical and Environmental Sciences Ano de publicação: 2017 Tipo de documento: Artigo