Immunological surrogate endpoints to evaluate vaccine efficacy / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 1110-1114, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-296624
ABSTRACT
An immunological surrogate endpoints is a vaccine-induced immune response (either humoral or cellular immune) that predicts protection against clinical endpoints (infection or disease), and can be used to evaluate vaccine efficacy in clinical vaccine trials. Compared with field efficacy trials observing clinical endpoints, immunological vaccine trials could reduce the sample size or shorten the duration of a trial, which promote the license and development of new candidate vaccines. For these reasons, establishing immunological surrogate endpoints is one of 14 Grand Challenges of Global Health of the National Institutes of Health (NIH) and the Bill and Melinda Gates Foundation. From two parts of definition and statistical methods for evaluation of surrogate endpoints, this review provides a more comprehensive description.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Projetos de Pesquisa
/
Vacinas
/
Biomarcadores
/
Ensaios Clínicos como Assunto
/
Interpretação Estatística de Dados
/
Resultado do Tratamento
/
Alergia e Imunologia
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Preventive Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo
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