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Biological transport of minocycline by human periodontal ligament fibroblasts / 华西口腔医学杂志
West China Journal of Stomatology ; (6): 237-240, 2008.
Artigo em Chinês | WPRIM | ID: wpr-296667
ABSTRACT
<p><b>OBJECTIVE</b>To investigate biological transport of minocycline by human periodontal ligament fibroblasts (HPDLF). To verify the hypothesis of delivering medicine to periodontium and the whole body through the root canal.</p><p><b>METHODS</b>HPDLF and MC3T3-E1 cells were incubated in minocycline solutions. The intracellular antibiotics contents were measured by high performance liquid chromatography (HPLC) and the cell total protein was measured by Bradford protein assay.</p><p><b>RESULTS</b>HPLC was an accurate, sensitive method for measurement of the intracellular minocycline. The incubation time and cell property had significant effect on the intracellular minocycline contents (P< 0.01). The intracellular contents increased with extracellular concentration.</p><p><b>CONCLUSION</b>Minocycline can be transported by HPDLF. The transport is concentration-dependent, time-dependent and cell specific.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ligamento Periodontal / Transporte Biológico / Células Cultivadas / Fibroblastos / Minociclina / Antibacterianos Limite: Humanos Idioma: Chinês Revista: West China Journal of Stomatology Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ligamento Periodontal / Transporte Biológico / Células Cultivadas / Fibroblastos / Minociclina / Antibacterianos Limite: Humanos Idioma: Chinês Revista: West China Journal of Stomatology Ano de publicação: 2008 Tipo de documento: Artigo