Biocompatibility of a novel biological piezoelectric ceramic to the rat periosteum derived osteoblast / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 133-136, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-296696
ABSTRACT
<p><b>OBJECTIVE</b>A novel biological piezoelectric ceramic was made by beta-tricalcium phosphate (beta-TCP) and lithium sodium potassium niobate (LNK) piezoelectric ceramics. To study its biocompatibility to osteoblast isolated from the cranium of 1-day-old Sprague-Dawley mice.</p><p><b>METHODS</b>The biological piezoelectric ceramic TCPLNK1/10, TCPLNK5/5 respectively mixed by beta-TCP and LNK piezoelectric ceramic at the ratio of 1/10 and 5/5. Then osteoblasts were used and seeded respectively on the negative and positive surfaces of TCPLNK1/10 and TCPLNK5/5. Growth and proliferation of the osteoblasts on TCPLNK1/10 and TCPLNK5/5 surfaces were evaluated in vitro by means of scanning electron microscopy (SEM) examination, fluorescence dyeing of osteoblast skeleton protein and MTT assay.</p><p><b>RESULTS</b>Cell morphology of osteoblast on positive and negative surfaces of TCPLNK1/10 and TCPLNK5/5 was normal, and both adhesion and growth characteristics showed better than control group. The growing osteoblasts on the TCPLNK1/10 negative surface were significantly higher than others. The negative surface of TCPLNK1/10 possessed better osteogenesis potential than others in vitro.</p><p><b>CONCLUSION</b>The surface of TCPLNK may permit the imitation piezoelectric effect of natural bone for bone regeneration.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoblastos
/
Osteogênese
/
Óxidos
/
Periósteo
/
Crânio
/
Osso e Ossos
/
Regeneração Óssea
/
Fosfatos de Cálcio
/
Microscopia Eletrônica de Varredura
/
Cerâmica
Limite:
Animais
Idioma:
Chinês
Revista:
West China Journal of Stomatology
Ano de publicação:
2008
Tipo de documento:
Artigo
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