Effects of different compressive stress on biological characteristics of condylar chondrocytes of neonatal SD rats / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effects of different static compressive stress on the biological characteristics of the mandibular condylar chondrocytes (MCC).</p><p><b>METHODS</b>The static compressive stress with a magnitude of 12, 24, 36 kPa were exerted on the third passage of MCC for one hour. The MCC was dyed by immunohisto-chemical method. The changes of the expression of collagen type I , II , III and proteoglycan (PG) were evaluated by a pathologic portraits analytic system.</p><p><b>RESULTS</b>The static compressive stress with a magnitude from 12 to 24 kPa can enforce the expression of collagen type I , II, III and PG of MCC. However, the decrease of expression of collagen type I and PG of MCC was detected when exerted by the static compressive stress with a magnitude from 24 kPa to 36 kPa.</p><p><b>CONCLUSION</b>The static stress of proper magnitude can make MCC more differentiate. However, the static stress of over-magnitude may make the biological characteristics of MCC weaken and express some characteristics of dedifferentiation.</p>