Study of the relationship between glutathione S-transferase genetic polymorphisms M1 and T1 and susceptibility to primary liver cancer in Chinese: a meta-analysis / 中华肝脏病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the association of genetic polymorphism of glutathione S-transferase (GSTM1 and GSTT1) with susceptibility to primary liver cancer in Chinese.</p><p><b>METHODS</b>Literature search of the PubMed, Chinese National Knowledge Infrastructure, and ISI Web of Science databases identified 25 relevant case-control studies of glutathione S-transferase genetic polymorphisms and primary liver cancer, representing a total of 2788 cases and 5548 controls. The extracted data was applied to the RevMan v4.2 software for meta-analysis. Data with significant heterogeneity was assessed by the fixed effects model, otherwise a random effects model was applied. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.</p><p><b>RESULTS</b>The correlation between the GSTM1 and GSTT1 null genotypes and susceptibility to primary liver cancer showed statistical significance (cases P = 1.8 * 10(-11) and controls P = 4.6 * 10(-11); Pearson's Chi-squared test). The OR value for GSTM1 was 1.67 (95% CI 1.39-2.01) and for GSTT1 was 1.59 (95% CI 1.26-1.96). In the GSTM1-GSTT1 interaction analysis, both GSTM1 and GSTT1 were null genotypes with OR = 3.34 (95% CI 2.23-5.00), which was higher than the null genotype for either one of them alone and which indicated higher relative susceptibility. Compared with individuals for whom both GSTM1 and GSTT1 were non-null genotypes, the presence of at least one null genotype showed higher risk of primary liver cancer.</p><p><b>CONCLUSION</b>The null genotypes of glutathione S-transferase genetic polymorphisms GSTM1 and GSTT1 are risk factors for primary liver cancer respectively, and their associated risk is increased when both are present.</p>