Research advances in pharmacogenomics of mercaptopurine / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1027-1033, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-297161
ABSTRACT
Mercaptopurine is a common chemotherapeutic drug and immunosuppressive agent and plays an important role in the treatment of acute lymphoblastic leukemia and inflammatory bowel disease. It may cause severe adverse effects such as myelosuppression, which may result in the interruption of treatment or complications including infection or even threaten patients' lives. However, the adverse effects of mercaptopurine show significant racial and individual differences, which reveal the important role of genetic diversity. Recent research advances in pharmacogenomics have gradually revealed the genetic nature of such differences. This article reviews the recent research advances in the pharmacogenomics and individualized application of mercaptopurine.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacogenética
/
Polimorfismo Genético
/
Pirofosfatases
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Genética
/
Mercaptopurina
/
Metabolismo
/
Metiltransferases
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2017
Tipo de documento:
Artigo
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