Clinical effects of different therapeutic regimens for Helicobacter pylori infection in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 672-676, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-297228
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical effects of sequential therapy, triple therapy, sequential therapy combined with Lactobacillus, and triple therapy combined with Lactobacillus in the eradication of Helicobacter pylori (H.pylori) infection in children.</p><p><b>METHODS</b>A total of 416 children with H.pylori infection were randomly assigned to sequential group (102 children), triple group (100 children), sequential-Lactobacillus group (109 children), and triple-Lactobacillus group (105 children). The clinical outcome, H.pylori eradication rate, cost-effect ratio, and incidence of adverse events were compared between the four groups.</p><p><b>RESULTS</b>The sequential-Lactobacillus and triple-Lactobacillus groups had significantly better clinical outcomes than the sequential group and the triple group (P<0.05). The sequential-Lactobacillus group had the highest marked response rate, followed by the triple-Lactobacillus group. The triple group had the lowest marked response rate. The sequential-Lactobacillus group also had the highest H.pylori eradication rate, followed by the triple-Lactobacillus group. The triple group had the lowest H.pylori eradication rate (P<0.05). The sequential group had the lowest cost-effect ratio, followed by the sequential-Lactobacillus group. The triple group had the highest cost-effect ratio (P<0.01). The sequential-Lactobacillus group had the lowest incidence rate of adverse events, followed by the triple-Lactobacillus group. The triple group had the highest incidence rate.</p><p><b>CONCLUSIONS</b>Sequential therapy combined with Lactobacillus seems to be the best regimen for the eradication of H.pylori infection in children.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Helicobacter pylori
/
Infecções por Helicobacter
/
Probióticos
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Lactobacillus
Limite:
Adolescente
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2017
Tipo de documento:
Artigo
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