Treating irritable bowel syndrome by wuling capsule combined pinaverium bromide: a clinical research / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 415-418, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-297415
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of wuling Capsule combined with Pinaverium Bromide in treatment of irritable bowel syndrome (IBS).</p><p><b>METHODS</b>Sixty-four IBS patients were randomized into two groups, the treatment group and the control group, 32 in each group. Patients in the treatment group took wuling Capsule (0. 33 g/capsule, 3 times per day) and Pinaverium Bromide (50 mg/tablet, one tablet each time, 3 times per day) , while those in the control group only took Pinaverium Bromide (50 mg/tablet, one tablet each time, 3 times per day). The therapeutic course for all was 6 weeks. IBS symptom score questionnaire, IBS-Quality of Life (IBS-QOL) , Self-Rating Depression Scale (SDS) , and Self-Rating Anxiety Scale (SAS) were assessed before and after treatment. Adverse reactions were also observed.</p><p><b>RESULTS</b>The improvement of abdominal pain, stool frequency, and stool properties, as well as changing rates of integrals were significantly higher in the treatment group than in the control group (P <0. 05). The improvement of dysphoria, body image, concerns for health, and dietary restriction of IBS-QOL, as well as changing rates of integrals were significantly higher in the treatment group than in the control group (P <0. 05). The improvement of SDS and SAS, as well as changing rates of integrals were significantly higher in the treatment group than in the control group (P <0. 05). No severe adverse reaction occurred in either group.</p><p><b>CONCLUSION</b>Combination therapy of wuling Capsule and Pinaverium Bromide could improve abdominal pain and defecation, attenuate depression and anxiety of IBS patients with higher safety.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ansiedade
/
Transtornos de Ansiedade
/
Qualidade de Vida
/
Cápsulas
/
Medicamentos de Ervas Chinesas
/
Morfolinas
/
Inquéritos e Questionários
/
Defecação
/
Pesquisa Biomédica
/
Síndrome do Intestino Irritável
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo
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