HCN ion channel: biological characteristics and functions in pain / 生理学报
Acta Physiologica Sinica
;
(6): 423-430, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-297475
ABSTRACT
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in vertebrate are reverse voltage-dependent, and its activation depends on the hyperpolarization of cell and may be directly or indirectly regulated by the cyclic adenosine monophosphate (cAMP) or other signal transduction cascades. The distribution, quantity, and activation states of HCN channels differ in tissues throughout the body. By modulating If/If current, HCN channels may influence the resting membrane potential, and thus importantly regulate neuronal excitability, dendritic integration of synaptic potentials, and synaptic transmission. Evidence exhibits that HCN channels participate in pain and other physiological and pathological process. Pharmacological treatment targeting HCN channels is of benefit to relieve pain and other related diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dor
/
Fisiologia
/
Canais de Potássio
/
Transmissão Sináptica
/
Canais Disparados por Nucleotídeos Cíclicos Ativados por Hiperpolarização
/
Potenciais da Membrana
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2014
Tipo de documento:
Artigo
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