Progress on PI3K/Akt signaling pathway regulating self-renewal and pluripotency of embryonic stem cells / 生理学报
Acta Physiologica Sinica
;
(6): 223-230, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-297497
ABSTRACT
The phosphatidylinositol 3-kinase (PI3K) and its downstream target protein kinase B (Akt/PKB) can be activated by a variety of extracellular and intracellular signals. They are important signaling molecules and key survival factors involved in cell proliferation, differentiation, apoptosis and other cellular processes. Recently, many reports demonstrate that type I PI3K/Akt signaling pathway plays an important role in maintenance of self-renewal and pluripotency of embryonic stem (ES) cells. Further studies with regard to the self-renewal and pluripotency of ES cells and underlying molecular mechanisms are crucial to its application in cell replacement therapy, regenerative medicine and tissue engineering. The present review focuses on the recent progress on the mediation of PI3K/Akt signaling pathway on the maintenance of self-renewal and pluripotency of ES cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Transdução de Sinais
/
Diferenciação Celular
/
Fosfatidilinositol 3-Quinases
/
Biologia Celular
/
Células-Tronco Pluripotentes
/
Proliferação de Células
/
Proteínas Proto-Oncogênicas c-akt
/
Células-Tronco Embrionárias
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2014
Tipo de documento:
Artigo
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