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Relationship between dust exposure and chronic obstructive pulmonary diseases and heat shock protein 72 and 73 in lymphocytes among coal miners / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases ; (12): 540-543, 2006.
Artigo em Chinês | WPRIM | ID: wpr-297660
ABSTRACT
<p><b>OBJECTIVE</b>To assess the expression of Hsp72 and Hsp73 in chronic obstructive pulmonary disease (COPD) and to evaluate their roles in damage from coal dust exposure.</p><p><b>METHODS</b>A case control study of 50 coal miners suffering from COPD and 50 healthy coal miners were selected from one coal mine. The levels of Hsp72 and Hsp73 in peripheral blood lymphocytes were determined by flow cytometry for all subjects.</p><p><b>RESULTS</b>(1) The expression of basic Hsp72 of peripheral blood lymphocytes for patients and controls was not different from that inducible expressed Hsp72 by 42 degrees C heat stress or by BPDE exposure. (2) The expression of Hsp72 in COPD patients (17.7 +/- 4.9) was significantly lower than that in healthy coal miners (22.6 +/- 10.0) (P < 0.01). On the other hand, the expression of Hsp73 in COPD patients (33.5 +/- 11.7) was higher than that in healthy coal miners (19.6 +/- 5.9) (P < 0.01). (3) A-positive relationship between the expression of Hsp72 and cumulative inhaling coal dust exposure was observed. No relationship was found between Hsp73 and cumulative inhaling coal dust exposure.</p><p><b>CONCLUSION</b>The decreased expressions of Hsp72 in peripheral blood lymphocytes of COPD coal miners.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Linfócitos / Estudos de Casos e Controles / Exposição Ocupacional / Minas de Carvão / Doença Pulmonar Obstrutiva Crônica / Poeira / Proteínas de Choque Térmico HSC70 / Proteínas de Choque Térmico HSP72 / Citometria de Fluxo / Metabolismo Tipo de estudo: Estudo observacional Limite: Idoso / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Industrial Hygiene and Occupational Diseases Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Linfócitos / Estudos de Casos e Controles / Exposição Ocupacional / Minas de Carvão / Doença Pulmonar Obstrutiva Crônica / Poeira / Proteínas de Choque Térmico HSC70 / Proteínas de Choque Térmico HSP72 / Citometria de Fluxo / Metabolismo Tipo de estudo: Estudo observacional Limite: Idoso / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Industrial Hygiene and Occupational Diseases Ano de publicação: 2006 Tipo de documento: Artigo