Detection of DD3 mRNA in the urine of prostate cancer patients and its clinical significance / 中华男科学杂志
National Journal of Andrology
;
(12): 511-513, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-297694
ABSTRACT
<p><b>OBJECTIVE</b>To detect the differential display code 3 mRNA (DD3 mRNA) in the urine sample of patients with prostate cancer and to evaluate its clinical significance.</p><p><b>METHODS</b>DD3 mRNA in the urine collected from 48 patients with prostate cancer, 23 patients with benign prostate hyperplasia (BPH) and 9 healthy male volunteers was measured by reverse transcriptase polymerase chain reaction (RT-PCR).</p><p><b>RESULTS</b>DD3 products could not be detected in the urine samples of the BPH patients and healthy male volunteers, but could in 39/48 urine samples of the patients with prostate cancer. Significant difference was found between them (P < 0.01).</p><p><b>CONCLUSION</b>The detection of DD3 mRNA in the urine promises to be a non-invasive, simple and sensitive method for the early diagnosis and post-treatment monitoring of prostate cancer.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias da Próstata
/
Urina
/
RNA Mensageiro
/
Sensibilidade e Especificidade
/
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Diagnóstico
/
Genética
/
Antígenos de Neoplasias
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Limite:
Idoso
/
Aged80
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2007
Tipo de documento:
Artigo
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